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In MCF-7 cancer cells, the overexpression of CAT affects their proliferation and migration and reduces their sensitivity to anticancer treatment [25]
Beyond its principal effects in glucose-decrease, this drug could reduce endothelial dysfunction, inducing nitric oxide production, activating cellular energy pathways, and reducing the expression of some inflammatory markers as Endothelin 1 (ET-1) (200, 201)
[1] Your GP can assess whether side effects are manageable with supportive measures, require dose adjustment, or necessitate discontinuation of treatment
Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer
However, weight loss induced by GLP-1RAs encompasses both fat and lean tissue compartments and could be associated to nutritional deficiencies, raising important questions regarding their impact on skeletal muscle, particularly in individuals at increased risk of sarcopenia [11]
GSH-responsive drug delivery system for active therapy and reducing the side effects of bleomycin
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